Endocrine Abstracts

Interleukin-6 (IL-6) has been shown to be involved in the pathogenesis of several bone diseases characterized by an imbalance between bone resorption and formation. Lately we have published our data suggesting an important role of IL-6 in thyrotoxicosis-related osteoporosis in mice (Horm Metab Res 2007 39 1–5).Aim: The aim of the study was to estimate serum markers of bone turnover: osteoclast-derived tartrate-resistant acid phosphatas...

Interleukin-6 (IL-6) has been shown to be involved in the pathogenesis of several bone diseases characterized by a negative balance between bone resorption and formation.The aim of the study was to estimate serum markers of bone turnover: osteoclast-derived tartrate-resistant acid phosphatase form 5a (TRACP 5b) and osteocalcin in IL-6 knock-out mice to assess the role of IL-6 in the pathogenesis of thyrotoxicosis-related disturbances of bone metabolism.<...